Synthesis and biological evaluation of 10-oxa-11-deoxyprostaglandin E1 and 10-nor-9,11-secoprostaglandin F1 and their derivatives
- 1 April 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (4) , 321-325
- https://doi.org/10.1021/jm00202a001
Abstract
Three 10-oxa-11-deoxyprostaglandin E1 and two 10-nor-9,11-secoprostaglandin F1 analogues were prepared. The compounds were evaluated for pregnancy interruptions [hamster], oxytocin-like activity (uterine strip [hamster]) and antiprostaglandin activity. One of the 10-nor-9,11-secoprostaglandin F1 analogues displayed activity as a prostaglandin E2 antagonist in the gerbil colon smooth muscle preparation.This publication has 0 references indexed in Scilit: