On the Site of Origin of Erythropoietic Factors in Human Fetal Tissues

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Abstract
Media conditioned with primary kidney cells or with liver parenchymal cells prepared from human midterm fetuses were able to stimulate heme synthesis in fetal liver erythroid cells. No significant effects were seen with media conditioned with human fetal lung cells although the experiments suggest a possible stimulation using cells prepared from older fetuses (11-16 weeks). It appears that at midterm, fetal liver parenchymal cells may be actively involved in the regulation of human hepatic erythropoiesis and that already at this early stage of gestation the fetal kidney cells may also play a role in the stimulation of heme synthesis by hepatic erythroid cells.