The “Typical” and “Atypical” Forms of Serum Insulin

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Abstract
"Atypical" ILA may be demonstrated in serum by fat-pad bioassay in the presence of an excess of insulin-antibody, and this is probably a product formed by the liver from "typical" insulin secreted by the pancreas. The physiological role served by the body''s transformation of some "typical" insulin into "atypical" insulin might be to divert the action of some insulin more exclusively to fat tissue, but this remains as yet a mystery, as does also the important question of whether disorder of this transfer may sometimes lead to diabetes mellitus or to other disease.