Cortisol Excretion Levels and Daytime Sleep in One-Year-Old Infants

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Abstract
Urine was collected from 20 oneyear-old infants from the time of awakening in the morning for 8 consecutive h. Free cortisol was measured by competitive protein-binding analysis in each urine sample. The mean cortisol excretion rate for the entire collection period was .228 ± .019 βg/h/kg. The mean excretion rate of sleeprelated cortisol (1.86 ± .28 βg/h) was significantly different from the mean rate for awake periods (2.61 ± .28 βg/h). The difference could not be attributed to time of day. The results suggest a direct relationship between cortisol production and daytime sleep-wake states in the one-year-old.

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