Proteins Originating in the Kidney in theUrine of Patients with Hypokalemia

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Abstract
Urine specimens from 13 patients with chronic potassium deficiency were analyzed for tissue-like material, using an immunoprecipitation technic with specific antikidney serum. Abnormal excretion of tissue-like material (histuria) was found in more than half of the samples. Sequential studies during potassium replacement showed this histuria to be transient, evolving in inverse proportion to the deficiency. There was no correlation between histuria and any other parameter, including total urinary protein output, electrophoretic picture, leukocyturia, metabolic disorders other than potassium deficiency, renal function, types and dosages of drugs absorbed. Hypokalemic histuria is the result of direct leakage of tissue constituents into the tubular lumen. This accounts in part for the mild proteinuria frequently observed during potassium deficiency in the absence of glomerular involvement.

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