The Effects of Inhibitors of Nucleic Acid and Protein Synthesis on the Replication of Spodoptera frugiperda Nuclear Polyhedrosis Virus in Cultured Spodoptera frugiperda Cells

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Abstract
The effects of inhibitors of nucleic acid and protein synthesis on the replication of Spodoptera frugiperda nuclear polyhedrosis virus have been determined. Two inhibitors of protein synthesis – cycloheximide and puromycin – were irreversible inhibitors of virus multiplication. Three inhibitors of nucleic acid synthesis – actinomycin D, cytosine arabinoside and camptothecin – prevented virus multiplication; only camptothecin was reversible. Rifampicin had no effect on virus multiplication.

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