Mixed Connective Tissue Disease and Sjoegren's Syndrome, Accompanied by HTLV-I Infection.
- 1 January 1993
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 32 (3) , 261-264
- https://doi.org/10.2169/internalmedicine.32.261
Abstract
A 48-year-old Japanese woman with mixed connective tissue disease (MCTD) and Sjögren's syndrome (SjS) was a carrier of HTLV-I and had anti-HTLV-I antibodies in her serum. Moreover, her peripheral blood lymphocytes contained proviral DNA for the pX region of HTLV-I as detected by the polymerase chain reaction. An immunohistological study was performed on her minor salivary gland to detect gene products of HTLV-I (P19 and P28 proteins); specific staining was demonstrated only in the epithelium of the salivary ducts. HTLV-I and its associated immune dysfunction may be responsible for MCTD and SjS in this patient.Keywords
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