Anticomplementary Action of Endotoxin.

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Abstract
Summary These results have indicated that the anticomplementary action of endo-toxin upon normal serum is not mediated by an Ag (endotoxin)-Ab complex. Removal of Ab from normal serum had no detectable effect upon such anticomplementary action. In addition, the serum of the newborn piglet obtained prior to feeding and relatively lacking in Ab was more susceptible to endo-toxin's anticomplementary action than the serum of its sow. Other ancillary evidence such as the marked difference in the susceptibility of the C′ of different species to endo-toxin also supports a non-immunological mechanism for its anticomplementary action. Although an Ag (endotoxin)-Ab complex may possess potent C′fixing action, other mechanisms, unknown at present, are responsible probably for the anticomplementary action of endotoxin in normal serum.