Time-Delayed Two-Step Selective Laser Photodamage of Dye-Biomolecule Complexes

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Abstract
A scheme is proposed for laser-selective photodamage of biological molecules, based on time-delayed two-step photoionization of a dye molecule bound to the biomolecule. The validity of the scheme is experimentally demonstrated in the case of the dye Proflavine, bound to synthetic polynucleotides.