EFFECTS OF HORMONE REPLACEMENT THERAPY ON LIPID PEROXIDES AND OXIDATION SYSTEM IN POSTMENOPAUSAL WOMEN
- 14 January 2000
- journal article
- clinical trial
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health, Part A
- Vol. 59 (1) , 1-5
- https://doi.org/10.1080/009841000157023
Abstract
A short-term evaluation of 6 months of estrogen therapy on oxidant status in 38 postmenopausal women was conducted. The levels of serum lipid peroxidation products, glutathione (GSH) status, and glutathione-related enzymes were evaluated before and after 6 months of hormone replacement therapy. After 6 months of estrogen treatment there was a significantly increased concentration of thiobarbituric acid-reactive substances (TBARS), which are an end product of lipid peroxidation. This was accompanied by a significant increase in the activity of glutathione peroxidase (GSH-Px). However, the activities of glutathione reductase (GSSG-R) and superoxide dism utase (SOD) were significantly decreased and total protein thiols were reduced. Data suggest that hormone replacement therapy in postmenopausal women is associated with oxidant mechanisms.Keywords
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