Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
Open Access
- 1 July 2002
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (13) , 6857-6862
- https://doi.org/10.1128/jvi.76.13.6857-6862.2002
Abstract
Nef enhances the serine phosphorylation of the human immunodeficiency virus type 1 matrix (MA) protein, which suggests that MA may be a functional target of Nef. Using mutants that remain infectious despite the absence of most or all of MA, we show in the present study that the ability of Nef to enhance virus infectivity is not compromised even if MA is entirely replaced by a heterologous lipid anchor.Keywords
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