High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin
Open Access
- 1 August 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (8) , 3193-3195
- https://doi.org/10.1128/aac.48.8.3193-3195.2004
Abstract
Of 595 isolates of Streptococcus pneumoniae from outpatients with respiratory tract infections, collected from 17 microbiology laboratories, 14.1% were resistant to erythromycin. Eighty-three erythromycin-resistant isolates were genetically analyzed, 83.1% of which harbored the ermB gene. Only four isolates (4.8%) harbored the mefA gene. Telithromycin exhibited potent activity against all isolates.Keywords
This publication has 20 references indexed in Scilit:
- Ribosomal Mutations Conferring Resistance to Macrolides in Streptococcus pneumoniae Clinical Strains Isolated in GermanyAntimicrobial Agents and Chemotherapy, 2003
- Macrolide Resistance by Ribosomal Mutation in Clinical Isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 StudyAntimicrobial Agents and Chemotherapy, 2003
- Macrolide-Resistant Streptococcus pneumoniae and Streptococcus pyogenes in the Pediatric Population in Germany during 2000-2001Antimicrobial Agents and Chemotherapy, 2003
- Failure of Macrolide Antibiotic Treatment in Patients with Bacteremia Due to Erythromycin‐ResistantStreptococcus pneumoniaeClinical Infectious Diseases, 2002
- Comparison of In Vitro Activities of ABT-773 and Telithromycin against Macrolide-Susceptible and -Resistant Streptococci and StaphylococciAntimicrobial Agents and Chemotherapy, 2002
- The responsibility of the pharmaceutical industryClinical Microbiology & Infection, 2001
- Macrolide-Resistant Streptococcus pneumoniae in Canada during 1998–1999: Prevalence of mef (A) and erm (B) and Susceptibilities to KetolidesAntimicrobial Agents and Chemotherapy, 2001
- Antimicrobial Resistance of Streptococcus pneumoniae Recovered from Outpatients with Respiratory Tract Infections in Germany from 1998 to 1999: Results of a National Surveillance StudyJournal of Clinical Microbiology, 2001
- Identification of an erm (A) Erythromycin Resistance Methylase Gene in Streptococcus pneumoniae Isolated in GreeceAntimicrobial Agents and Chemotherapy, 2001
- Carriage of Internationally Spread Clones ofStreptococcus pneumoniaewith Unusual Drug Resistance Patterns in Children Attending Day Care Centers in Lisbon, PortugalThe Journal of Infectious Diseases, 2000