Effect of Murine Tumor Sera on Adsorption of IgG-Sensitized Erythrocytes by Murine Sarcoma Tissue
- 1 March 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 154 (3) , 365-367
- https://doi.org/10.3181/00379727-154-39672
Abstract
Previous work showed that the adsorption of Ig[immunoglobulin]G antibody-sensitized erythrocytes by tumor and normal spleen tissues can be inhibited by immune complexes and heat-aggregated IgG. The present study showed that sera from mice immunized with syngenic tumor cells inhibited adsorption of sensitized erythrocytes by tumor and spleen tissues. These sera also inhibited hemadsorption by allogenic tumor tissue and, significantly, by syngenic as well as allogenic spleen tissue. Sera from tumor-bearing animals apparently contain immune complexes which block the Fc receptors of tumor and spleen cells indiscriminately.This publication has 3 references indexed in Scilit:
- Tumor-Associated Blocking Factors: Isolation from Sera of Tumor-Bearing MiceThe Journal of Immunology, 1976
- The Raji cell radioimmune assay for detecting immune complexes in human sera.Journal of Clinical Investigation, 1976
- Antibody-Mediated Hemadsorption by Tumor TissuesInternational Archives of Allergy and Immunology, 1968