Anesthetic, Hypothermic, Myorelaxant and Anticonvulsant Effects of Synthetic Eugenol Derivatives and Natural Analogues
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 22 (2) , 113-127
- https://doi.org/10.1159/000137479
Abstract
Nine newly synthesized eugenol derivatives [acetyleugenol, .beta.-glucosyleugenol, phenyleugenol, benzyleugenol, phenylethyleugenol, 4''-aminophenyleugenol, 4''-nitrophenyleugenol, 2'',4''-dinitrophenyleugenol and dehydrodieugenol] were investigated in rats or mice as to their anesthetic, hypothermic, myorelaxant and anticonvulsant effects. Additional pharmacological activity which appeared during the experiments is described. For comparative purposes, 6 naturally-occurring eugenol analogs [eugenol, methyleugenol isoeugenol, methylisoeugenol, estragol and safrole] were included in the study. The results are further discussed as to possible structure-activity relationships between the test compounds and the 4 investigated effects.This publication has 0 references indexed in Scilit: