Changes in the Surface of Virus‐Infected Cells Recognized by Cytotoxic T Cells

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Abstract
P-815 [mouse] mastocytoma cells develop susceptibility to immune [mouse] T[thymus-derived]-cell-mediated cytolysis shortly after infection by ectromelia virus. Intracellular viral replication and late protein synthesis seem to be unnecessary events. Interference with early protein synthesis inhibits the development of susceptibility to lysis. The important intracellular events necessary for subsequent cytolysis appear to occur within 1 h of infection. Virus rendered noninfectious by UV irradiation, but not by .gamma. irradiation, is able to induce these changes. By determining the minimum and essential events of the infectious process which result in T-cell-mediated cytolysis, the task of establishing the molecular changes occurring in the target cell surface membrane necessary for immune T-cell recognition should be simplified.