Interleukin 1

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Abstract
• The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines. Initial studies focused on interleukin 1-like molecules produced by keratinocytes, initially termed epidermal cell-derived thymocyte activating factor (ETAF). It is now clear that the functional activities described by the term ETAF are composed mainly of interleukin 1α and interleukin 1β, although other epidermal cytokines may contribute to the biologic activity. The biologic properties of interleukin 1 are the basis of this review. (Arch Dermatol. 1989;125:679-682)