Allogeneic red blood cell transfusions: efficacy, risks, alternatives and indications
Open Access
- 14 October 2004
- journal article
- review article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 95 (1) , 33-42
- https://doi.org/10.1093/bja/aeh290
Abstract
Careful assessment of risks and benefits has to precede each decision on allogeneic red blood cell (RBC) transfusion. Currently, a number of key issues in transfusion medicine are highly controversial, most importantly the influence of different transfusion thresholds on clinical outcome. The aim of this article is to review current evidence on blood transfusions, to highlight ‘hot topics’ with respect to efficacy, outcome and risks, and to provide the reader with transfusion guidelines. In addition, a brief synopsis of transfusion alternatives will be given. Based on up-to-date information of current evidence, together with clinical knowledge and experience, the physician will be able to make transfusion decisions that bear the lowest risk for the patient.Keywords
This publication has 87 references indexed in Scilit:
- Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from bloodThe Lancet, 2004
- Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patientThe Lancet, 2004
- Does the storage time of transfused red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients?*Critical Care Medicine, 2004
- The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States*Critical Care Medicine, 2004
- Effects of storage on efficacy of red cell transfusion: When is it not safe?Critical Care Medicine, 2003
- Transfusion-related acute lung injuryTransfusion Medicine Reviews, 2003
- Transfusion triggers: A systematic review of the literature*Transfusion Medicine Reviews, 2002
- Effect of anaemia and cardiovascular disease on surgical mortality and morbidityThe Lancet, 1996
- Practice Guidelines for Blood Component TherapyAnesthesiology, 1996
- What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's WitnessesTransfusion, 1994