Synthesis of Macrocarbocycles Utilizing Intramolecular 1,3-Dipolar Cycloaddition of Nitrile Oxides. Synthesis of (±)-Muscone

Abstract
Intramolecular 1,3-dipolar cycloaddition of nitrile oxides generated from ω-nitro-1-alkenes gave isoxazoline-fused macrocarbocycles (ring size 12, 14, 15, and 16) in fair to good yields. The 15-membered derivative was converted into (±)-muscone.