Effects of diet and type IIa hyperlipoproteinemia upon structure of triacylglycerols and phosphatidyl cholines from human plasma lipoproteins

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Abstract
Four normal and two individuals with Type IIa hyperlipoproteinemia were placed on the National Heart and Lung Institute Type IIa diet (low cholesterol, sn-1 position and mostly 18∶1 in positionssn-2 and 3. There was a marked difference in the distribution of 18∶2 in low density lipoproteins of the normal and Type IIa individuals. The control contained equal amounts of 18∶2 in thesn-1 andsn-3 positions, whereas IIa low density lipoprotein was asymmetric with 26% of the 18∶2 in positionsn-1 and 3% in thesn-3 position. Very low density lipoprotein was asymmetric with regard to 18∶2 in control and IIa samples with an average of 5% of the 18∶2 in positionsn-1 and 40% in positionsn-3. The phosphatidyl cholines contained predominantly 16∶0 and 18∶0 in positionsn-1, whereas the acids in positionsn-2 were unsaturated with very little difference between lipoprotein classes. Neither the short dietary periods nor source of plasma affected the structure of the phosphatidyl cholines.

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