Characterization of γ-Glutamylcysteine Synthetase, an Essential Enzyme in the Biosynthesis of Trypanothione (Diglutathionylspermidine)
Open Access
- 1 July 1996
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 271 (29) , 17485-17490
- https://doi.org/10.1074/jbc.271.29.17485
Abstract
No abstract availableKeywords
This publication has 44 references indexed in Scilit:
- Molecular Cloning and Nucleotide Sequencing of the -Glutamylcysteine Synthetase Gene of the Fission Yeast Schizosaccharomyces pombeThe Journal of Biochemistry, 1995
- Cloning and Sequencing of the cDNA for the Light Subunit of Human Liver γ-Glutamylcysteine Synthetase and Relative RNA Levels for Heavy and Light Subunits in Human Normal TissuesBiochemical and Biophysical Research Communications, 1995
- 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegansNature, 1994
- Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class EnzymesJournal of Molecular Biology, 1993
- Three-dimensional Structure of the Glutathione Synthetase from Escherichia coli B at 2·0 Å ResolutionJournal of Molecular Biology, 1993
- Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetaseBiochemical and Biophysical Research Communications, 1992
- The P-loop — a common motif in ATP- and GTP-binding proteinsTrends in Biochemical Sciences, 1990
- Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: Substrate crystal structures at 2Å resolutionJournal of Molecular Biology, 1989
- Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in TrypanosomatidsScience, 1985
- Inhibition of γ-glutamylcysteine synthetase by cystamine; An approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria)Biochemical and Biophysical Research Communications, 1977