Clinical trials, reviews, and the Journal of Negative Results.
Open Access
- 1 January 1981
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 11 (1) , 15-18
- https://doi.org/10.1111/j.1365-2125.1981.tb01095.x
Abstract
1 Eighteen our of twenty non-significant placebo controlled trials are shown to have trends favouring imipramine and are consistent with a further ten significant at 0.05. 2 The problems of falsely positive and falsely negative results are discussed. A plea is made to medical journal editors to publish 'negative' or null difference trials by title only; rather than not at all.Keywords
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