Circadian variation in disease activity in rheumatoid arthritis.
- 20 February 1982
- Vol. 284 (6315) , 551-554
- https://doi.org/10.1136/bmj.284.6315.551
Abstract
Disease activity in rheumatoid arthritis as measured by repeated estimation of joint pain, stiffness, articular index, and grip strength was shown to have a circadian rythm, maximal activity being seen between 0200 and 0400 and minimal activity in the early afternoon. This variation in disease activity may be related to circadian alterations in immune and inflammatory responses (such as immune complexes and neutrophil function) dependent on alterations in circulating concentrations of steroids. The circadian variation in disease activity has important implications in assessment of patients, prescription of drugs, and performance of drug trials.This publication has 11 references indexed in Scilit:
- Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeutic effectiveness of flurbiprofen at different times of day.British Journal of Clinical Pharmacology, 1981
- A simple enzyme immunoassay for the demonstration of rheumatoid factorJournal of Immunological Methods, 1979
- Methods for cosinor-rhythmometry.1979
- Circadian variation in an immune response in man.BMJ, 1978
- Glucocorticosteroid Therapy: Mechanisms of Action and Clinical ConsiderationsAnnals of Internal Medicine, 1976
- Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus.1976
- Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.1968
- Scientific assessment of the results of physical treatment--measurement of stiffness.1966
- Morning Stiffness in Rheumatoid ArthritisAnnals of the Rheumatic Diseases, 1960
- 1958 Revision of diagnostic criteria for rheumatoid arthritis.1958