Molecular Characteristics of Some Carcinogenic Hydrocarbons
- 1 June 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (6) , 1251-1253
- https://doi.org/10.1073/pnas.68.6.1251
Abstract
The chemical reactivity and presumably the carcinogenic activity induced in aromatic hydrocarbons by hydroxylating enzymes may be due to the generation of electrophilic centers in some (benzo[a]pyrene) or nucleophilic centers in others (7,12-dimethylbenz[a]anthracene or 3-methylcholanthrene). These centers, which are at positions complementary to the points of activation by acid-derived protons (models of the positive oxygen of the hydroxylating enzymes), may react simultaneously with corresponding cellular components.Keywords
This publication has 20 references indexed in Scilit:
- Transformation of Rat and Hamster Embryo Cells by Extracts of City SmogProceedings of the National Academy of Sciences, 1971
- Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesisPublished by Elsevier ,1970
- The metabolism of some aromatic hydrocarbons by mouse embryo cell culturesBiochemical Pharmacology, 1970
- Nuclear electron transport I electron transport enzymes in bovine liver nuclei and nuclear membraneBiochemical and Biophysical Research Communications, 1970
- ONCOGENES OF RNA TUMOR VIRUSES AS DETERMINANTS OF CANCERProceedings of the National Academy of Sciences, 1969
- One electron transfer oxidation of 7,12-dimethylbenz[.alpha.]anthracene, a model for the metabolic activation of carcinogenic hydrocarbonsJournal of the American Chemical Society, 1967
- Hydroxylation-Induced Migration: The NIH ShiftScience, 1967
- The metabolism of benzo[a]pyrene by rat-liver homogenatesBiochemical Pharmacology, 1967
- Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic AcidNature, 1964
- Electronic Structure and Carcinogenic Activity of Aromatic Molecules New DevelopmentsAdvances in Cancer Research, 1955