Effects of Roentgen Irradiation on the Tumor Bed: I. The Inhibiting Action of Local Pretransplantation Roentgen Irradiation (1500 r a ) on the Growth of Mouse Mammary Carcinoma

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Abstract
Pretransplantation irradiation with a dose of 1500 r/air of X-rays with a half-value layer of 4.2 mm aluminum delivered locally to one leg 48 hours before the subcutaneous inoculation of a tumor cell suspension inhibits the development and the growth-rate of mouse mammary carcinoma. This finding has been established statistically in several experiments (p < .001). Quantitative differences in response have been shown between different tumor lines of the same type of mammary carcinoma. Since the tumor tissue itself has received no irradiation, the inhibition is due to radiation effects on the tumor bed or the normal tissues in which the tumor grows.

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