Variation among inbred strains of mice in adenosine 3′:5′ cyclic monophosphate levels of spermatozoa

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Abstract
SUMMARY: Spermatozoa from inbred strains of mice were found to vary significantly for levels of cyclic AMP when extractions were performed in a reproducible manner. The F1hybrid between high and low spermatozoal cAMP strains showed spermatozoal cAMP levels typical of the low strain. An analysis of spermatozoal cAMP in individual mice from the back-cross of the F1to the high strain suggested that alleles at more than one locus determine strain differences in spermatozoal cAMP. The major histocompatibility locus of mice,H-2, which had been found to have an effect on liver cAMP levels did not seem to affect spermatozoal cAMP levels.t-Alleles, which appear to alter fertilization rates by effects on motility, had no apparent affects on spermatozoal cAMP.