IMPORTANCE OF TREATMENT REGIMEN OF INTERFERON AS AN ANTI-TUMOR AGENT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (9) , 4172-4175
Abstract
A highly purified hybrid human leukocyte interferon, IFN-.alpha.AD, produced in Escherichia coli, was used to define optimum treatment conditions for L1210 leukemia in mice. Treatments prior to tumor inoculation were ineffective. Treatments from the 3rd day post-tumor inoculation were most effective, and treatments every 3rd day were more effective than were regimens involving more frequent treatments. IFN-.alpha.AD was effective in vivo against tumors formed from a line of L1210 cells resistant to IFN-.alpha.AD in cell cultures. These and other results indicate the importance and nature of indirect mechanisms of action for efficacy of interferons against tumors.