Synthesis of 2-Substituted Indoles via Pd/C-Catalyzed Reaction in Water
- 6 August 2004
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2004 (11) , 1965-1969
- https://doi.org/10.1055/s-2004-830861
Abstract
A general and one-pot synthesis of 2-alkyl/aryl substituted indoles via a tandem Pd/C mediated coupling/5-endo-dig cyclization of terminal alkynes (including acetylenic carbinols) with o-iodoanilides in water is reported. The reaction is carried out using PPh3 and CuI as co-catalysts and 2-aminoethanol as a base. The reaction appears to tolerate a variety of functional groups present in the alkynes and does not require the use of any organic co-solvent. DRL publication No 427.Keywords
This publication has 0 references indexed in Scilit: