Highly Enantioselective Catalytic Acyl-Pictet−Spengler Reactions
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- 7 August 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (34) , 10558-10559
- https://doi.org/10.1021/ja046259p
Abstract
The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.Keywords
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