The Effect of Cellular Aggregation On Pressure-Flow Relationships in the Microvascular System

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Abstract
The pressure-pulses in 60-250[mu] mesenteric arterioles of frogs were secured by a capacitance manometer through direct cannulation of the arterioles and blood flow was recorded in the same vessel simultaneously by means of split field cinephotomicrography before, during and after the injection of rabbit-anti-frog red-cell serum. Immediately after the injection of the antiserum the majority of the erythrocytes were agglutinated into masses which were often as wide as the vessel but no other component of the blood was involved in the reaction. The linear velocity of blood flow was sharply reduced but the pressure pulses after an initial increase in amplitude returned to the pre-injection level although their configuration was different. Shortly before death the pressure pulses decreased in amplitude and frequency falling to zero. The experiments indicated that in spite of the marked resistance to flow there was no concomitant change in pressure until the maintained reduction in flow probably decreased the interchange of metabolites between blood and tissue to interfere seriously with homeostasis.

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