Genetics and Biosynthesis of Complement Proteins

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Abstract
THE complement system consists of over 20 individual plasma proteins that interact in a highly specific manner to generate elements of the inflammatory response.1 2 3 A large number of genetic polymorphisms and deficiency states of complement proteins have been recognized during the past decade.4 These observations prompted further study of the biosynthesis of complement proteins, and these studies, in turn, have led to a partial understanding of the molecular basis of the genetic control of the complement system. Moreover, clinical studies of patients with a deficiency in complement have established its central role in four different host-defense mechanisms: the generation of . . .