Compartmentalization of protein kinase A signaling by the heterotrimeric G protein G o

Publisher Website
Google Scholar
Abstract
Go, a member of the Go/i family, is the most abundant heterotrimeric G protein in brain. Most functions of Go are mediated by the Gβγ dimer; effector(s) for its α-subunit have not been clearly defined. Here we report that Goα interacts directly with cAMP-dependent protein kinase (PKA) through its GTPase domain. This interaction did not inhibit the kinase function of PKA but interfered with nuclear translocation of PKA while sparing its cytosolic function. This regulatory mechanism by which Go bifurcates PKA signaling may provide insights into how Go regulates complex processes such as neuritogenesis, synaptic plasticity, and cell transformation.