The Role of Energy Metabolism in the Interaction between Amino Acid and Sugar Transport in the Small Intestine

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Abstract
The interaction between sugar and amino acid transport was studied in everted sacs of rat jejunum in vitro. The addition of the actively transported nonmetabolized sugars, D-galactose and α-methyl-D-glucoside, to the mucosal medium inhibited the active transport of cycloleucine (1-amino-cyclopentane-1-carboxylic acid). This effect was largely counteracted by the simultaneous presence of D-glucose in the serosal medium or of D-fructose. The results indicate that provision of substrates for energy metabolism relieves the inhibition of transport and supports the hypothesis that the interaction between the intestinal transport of sugar and of amino acid is at least in part due to competition for a limited supply of metabolic energy.

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