Nonlinear Pharmacokinetics Of Ethanol: The Disproportionate AUC‐Dose Relationship
- 1 October 1980
- journal article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 4 (4) , 384-390
- https://doi.org/10.1111/j.1530-0277.1980.tb04836.x
Abstract
Whole venous blood concentrations of ethyl alcohol were measured following the constant rate intravenous infusion of ethanol to four Beagle dogs. Five different doses (0.1–0.8 g ethanol/kg body weight) were administered at scheduled intervals. The area under the blood ethanol concentration-time curves (AUC) was found to demonstrate a markedly nonlinear relationship with the administered dose. Simulations of one and two compartment open models with Michaelis-Menten elimination kinetics and zero-order input are presented with their theoretical AUC-dose relationships.Keywords
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