THE RELATIONSHIP OF STREPTOLYSIN S INHIBITOR TO PHOSPHOLIPIDS IN THE SERUM OF HUMAN BEINGS AND EXPERIMENTAL ANIMALS

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Abstract
The in-hibition of the streptococcal hemolysin streptolysin S, by serum is associated with alpha and beta lipoproteins rather than with specific antibody. An attempt was made to correlate fluctuation in streptolysin S inhibitor (SSI) titer with variation in serum lipids. The relationship of the serum levels of total phospholipid, lecithin and sphingomyelin to the SSI titer was studied in patients with a variety of diseases. Fluctuations in total phospholipid, and particularly in lecithin levels, were associated with similar variations in SSL Diseases associated with the most marked increase of beta lipoprotein (biliary obstruction, xanthomatosis, nephrosis, etc.) showed the highest levels of SSI and phospholipids, while in rheumatic fever, and in occasional patients with protracted febrile states, subnormal phospholipid levels were accompanied by depression of the SSI titers. There was, however, a relatively wide range of lecithin values for any given titer of SSI. The induction of hyperphospholipemia in rabbits by repeated intraven. injns. of the nonionic detergent, Triton-20, by ligation of the common bile duct, and by feeding cholesterol results in an elevation of SSI titer. The SSI titer in mice may also be elevated by repeated intraperit. injns. of Triton A-20.