Suprathreshold glucose and fructose sensitivity in individuals with different family histories of non-insulin-dependent diabetes mellitus

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Abstract
Measures of perceived suprathreshold intensity of glucose and fructose were established by magnitude estimation in 19 non-diabetic subjects with first degree diabetic relatives and eight nondiabetic subjects with no known diabetic relatives. A subgroup of individuals having family histories of diabetes was isolated which evidenced decreased sensitivity to glucose (relative to fructose). This study represents the first evidence that suprathreshold measures of perceived glucose intensity are depressed in non-diabetic relatives of diabetics and lends support to the hypothesis that more than one receptor mechanism exists for the detection of sweet stimuli.