Leukaemic transformation of engrafted bone marrow cells

Publisher Website
Google Scholar
Abstract
Recurrent leukemia following bone marrow transplantation is most often due to the regrowth of original host leukemia cells, but may also be due to the malignant transformation of normal donor marrow cells after transplantation into a leukemia patient. The 9th case of malignant change in cells of donor origin was reported in a 12-yr-old boy who was originally diagnosed as having Ph1 + CML [chronic myelogenous leukemia]. He remained Ph1+ during lymphoid blast crisis. After transplantation with marrow from a cytogenetically normal sister, he relapsed to Ph1- ALL [acute lymphocytic leukemia] in the female donor cells. The marrow showed a mixed karyotype of 46,XX/46,XX,inv(9)(p12q12). Hematologically, the patient showed different manifestations of the same disease state. Cytogenetically, the pre- and post-transplant leukemias were different.