Enhanced seizures and hippocampal neurodegeneration following kainic acid‐induced seizures in metallothionein‐I + II‐deficient mice
- 1 July 2000
- journal article
- research article
- Published by Wiley in European Journal of Neuroscience
- Vol. 12 (7) , 2311-2322
- https://doi.org/10.1046/j.1460-9568.2000.00128.x
Abstract
Metallothioneins (MTs) are major zinc binding proteins in the CNS that could be involved in the control of zinc metabolism as well as in protection against oxidative stress. Mice lacking MT‐I and MT‐...Keywords
This publication has 54 references indexed in Scilit:
- Ectopic Expression of Metallothionein-III Causes Pancreatic Acinar Cell Necrosis in Transgenic MiceToxicology and Applied Pharmacology, 1998
- Oxidative Stress in Closed-Head Injury: Brain Antioxidant Capacity as an Indicator of Functional OutcomeJournal of Cerebral Blood Flow & Metabolism, 1997
- Constitutive Expression of Metallothionein-III (MT-III), but Not MT-I, Inhibits Growth When Cells Become Zinc DeficientToxicology and Applied Pharmacology, 1995
- Chemical modulation of metallothionein I and III mRNA in mouse brainNeurochemistry International, 1995
- Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)Brain Research, 1994
- Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brainFEBS Letters, 1994
- Nitric Oxide Destroys Zinc-Sulfur Clusters Inducing Zinc Release from Metallothionein and Inhibition of the Zinc Finger-Type Yeast Transcription Activator LAC9Biochemical and Biophysical Research Communications, 1994
- Development of a Competitive Double Antibody Radioimmunoassay for Rat MetallothioneinJournal of Immunoassay, 1993
- Metallothionein Reacts with Fe2+ and NO to Form Products with a g=2.039 ESR SignalBiochemical and Biophysical Research Communications, 1993
- Differential and sex-specific effects of kainic acid and domoic acid lesions in the lateral septal area of rats on immune function and body weight regulationExperimental Neurology, 1991