Effects of Histamine and Acetylcholine on Equine Digital Lymph Flow and Composition

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Abstract
The flow rate and protein concentration of lymph collected from a digital lymphatic in 8 anesthetized ponies were measured. Systemic arterial pressure (Part), and small vein pressure (Psy) were measured. Control lymph flow averaged 0.068 ml/min and contained 3.11 g/100 ml of protein with albumin/globulin ratio of 0.75. Local intra-arterial infusion of acetylcholine (10 .mu.g/min for 20 min) elevated Psv but did not increase lymph flow rate or protein concentration. A 60 min local intra-arterial infusion of histamine (10 .mu.g/min) produced a marked sustained increase in Psv and both lymph flow and protein concentration. Edema developed in the digit receiving histamine. In the horse histamine edema may be due primarily to a decreased transcapillary colloid osmotic pressure gradient rather than an increased transcapillary hydrostatic pressure gradient.

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