Immunity of Guinea-pigs to Diphtheria Toxin and its Effect upon the Offspring
- 1 July 1911
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 11 (2) , 220-234
- https://doi.org/10.1017/s0022172400016673
Abstract
1. Diphtheria toxin-antitoxin mixtures induce a higher immunity in guinea-pigs than sub-lethal doses of toxin; one injection of the mixture being sufficient to produce an immunity lasting in some cases for a period of over two years, as shown by the passive immunity conferred on the offspring.2. The highest immunity is produced by toxin-antitoxin mixtures containing the most uncombined toxoid.3. The active immunity of the mother is transferred passively to the offspring.4. The passive immunity thus transferred usually disappears at the end of two months after birth, and only in rare instances has been recongnised after three months.5. Immunity is mainly transmitted in utero, and only to a slight extent during lactation.6. Young bred from does that have been used for a single routine antitoxin test may be able to tolerate 14 times the does of diphtheria toxin fatal for a normal guinea-pig.Keywords
This publication has 4 references indexed in Scilit:
- Variation in Susceptibility of Guinea-pigs to Diphtheria ToxinEpidemiology and Infection, 1909
- The Degree and Duration of Passive Immunity to Diphtheria Toxin transmitted by immunized Female Guinea-Pigs to their immediate offspring.1907
- Ueber die Vererbung der Immunität bei TetanusMedical Microbiology and Immunology, 1894
- Ueber Immunität durch Vererbung und SäugungMedical Microbiology and Immunology, 1892