Antiproliferative effect of hu-interferon-gamma in 674V and J82 bladder carcinoma cell lines
- 1 November 1988
- journal article
- research article
- Published by Springer Nature in Urological Research
- Vol. 16 (6) , 403-405
- https://doi.org/10.1007/bf00280019
Abstract
Hu-IFN-gamma was evaluated in regard to the antiproliferative effect on J82 and 647V bladder cancer cell lines. In addition, the IFN-receptors were determined. There was a significant growth inhibition of J82 as well as 647V at low dose Hu-IFN-g (1 U/ml). The growth inhibition was significantly higher in 647V than in J82. The binding assay for 125J-Hu-IFN-g revealed 870 and 3,000 binding sites for 647V and J82, respectively, indicating that the antiproliferative effect of Hu-IFN-g may not depend on the absolute amount of IFN-receptors, in the two cell lines tested.Keywords
This publication has 18 references indexed in Scilit:
- IMMUNOMODULATORY AND IMMUNOTHERAPEUTIC PROPERTIES OF RECOMBINANT GAMMA-INTERFERON AND RECOMBINANT TUMOR-NECROSIS-FACTOR IN MICE1987
- Biological effects of γ‐interferon on human tumor cells: Quantity and affinity of cell membrane receptors for γ‐IFN in relation to growth inhibition and induction of HLA‐DR expressionInternational Journal of Cancer, 1985
- Differential action of six human interferons against two human carcinomas growing in nude miceInternational Journal of Cancer, 1985
- EFFECTS OF HUMAN RECOMBINANT ALPHA-2 ARG-INTERFERON AND GAMMA-INTERFERON ON HUMAN-BREAST CANCER CELL-LINES - DISSOCIATION OF ANTIPROLIFERATIVE ACTIVITY AND INDUCTION OF HLA-DR ANTIGEN EXPRESSION1985
- IFN gamma potentiates the induction of (2-5)A-synthetase in human tumor cells treated with IFN alpha and beta.1985
- Effect of Human Recombinant Alpha-2-and Gamma-Interferon on the Growth of Human Cell Lines from Solid Tumors and Hematologic MalignanciesJournal of Interferon Research, 1985
- Inhibition of the estradiol-induced growth of cultured human breast cancer cells by the anti-estrogens tamoxifen, desmethyl-tamoxifen, 4-hydroxy-tamoxifen and enclomipheneBiochemical Pharmacology, 1984
- Cytolytic activity of interferon‐gamma and its synergism with 5‐fluorouracilInternational Journal of Cancer, 1984
- Human interferon-gamma is internalized and degraded by cultured fibroblasts.Journal of Biological Chemistry, 1983
- The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassayBiochemical Journal, 1973