Halogenation Using N-Halogenocompounds. I. Effect of Amines on ortho-Bromination of Phenols with NBS
- 1 May 1993
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 66 (5) , 1576-1579
- https://doi.org/10.1246/bcsj.66.1576
Abstract
Primary and secondary amines, especially diisopropylamine and dibutylamine, catalyzed ortho-dibromination of phenol and ortho-monobromination of 2-substituted phenols with NBS in dichloromethane to give selectively 2,6-dibromophenol and 2-bromo-6-substituted phenols, respectively. The effective intermediates are inferred to be N-bromoamines. The scope and limitations of the bromination are also presented.This publication has 4 references indexed in Scilit:
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