CROSS-REACTIVITY OF HUMAN BETA2-MICROGLOBULIN WITH HUMAN GRANULOCYTE COLONY-STIMULATING ACTIVITY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (2) , 416-418
Abstract
The effects of [goat] antisera to human .beta.2-microglobulin (.beta.2m) on factors able to stimulate colony formation in culture by human granulopoietic progenitor cells were investigated. The colony-stimulating activity (CSA) present in media conditioned by cultures of human peripheral leukocytes was suppressed by treatment with anti-.beta.2m. This inhibition was not due to a direct effect on the granulopoietic progenitor cells; controls to test for cytotoxicity and for noncytotoxic inhibition of the progenitor cells by anti-.beta.2m yielded negative results. There is probably a relationship between human CSA and .beta.2m. A possible analogy exists between molecules involved in the in vitro regulation of granulopoiesis and products of the major histocompatibility gene complex.

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