Preparation of Ion-Exchange Silica and Effect of pH on Protein Binding of Ion-Exchange Silica

Abstract
The preparation of protein-compatible ion-exchange siliceous supports (DEAE, CM, and SP) utilizing the epoxy functionality of glycidoxypropyltrimethoxysilane is reported. The effects of pH on protein binding of these ion-exchange packings were also studied. Bovine serum albumin (BSA) and bovine γ-globulin (BγG) were chosen as representative proteins.