GLYCYRRHETINIC ACID-DERIVATIVES - A NOVEL CLASS OF INHIBITORS OF GAP-JUNCTIONAL INTERCELLULAR COMMUNICATION - STRUCTURE-ACTIVITY-RELATIONSHIPS

  • 1 September 1988
    • journal article
    • research article
    • Vol. 246  (3) , 1104-1107
Abstract
Glycyrrhetinic acid was shown previously to inhibit intercellular gap-junctional communication between human fibroblasts. In the present study 31 derivatives of glycyrrhetinic acid were tested for their ability to inhibit communication. Eight of the compounds inhibited communication with high potency (IC50 < 3 .mu.M) and showed low toxicity, properties which suggest they may be useful pharmacological probes for studies of gap-junction function.