UNGstoppable Switching
- 20 August 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5687) , 1113-1114
- https://doi.org/10.1126/science.1102692
Abstract
The enzymes AID, a DNA deaminase, and UNG are crucial for two processes (CSR and SHM) involved in the generation of antibody diversity in B cells. As Unniraman and colleagues point out in their Perspective, new findings about the action of UNG suggest a rethink of a popular model of CSR in which the central event is DNA deamination by AID ( Begum et al.)Keywords
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