Changes of urinary kallikrein and kinin excretions induced by adrenalin infusion in conscious dogs

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Abstract
A subpressor dose of adrenaline [epinephrine, A.] (0.5 mg/h) infused i.v. into 9 conscious trained dogs increased urine kinin excretion from 41 .+-. 9-191 .+-. 29 ng/h. The effect was abolished by phenoxybenzamine pretreatment (1 mg/kg). In .alpha.-blocked condition A increased urine TAMe[p-tosyl-l-arginine methyl ester]-esterase activity from 12.7 .+-. 2.3 mEU[enzyme activity unit]/h to 15.7 .+-. 2.8 mEU/h but in .beta.-blocked condition the catecholamine decreased urine enzyme activity from 12.7 .+-. 1.0 mEU/h to 11.7 .+-. 1.1 mEU/h. A invariably decreased urine Na excretion. In comparable experiments with dopamine (1.0 mg/h) a slight natriuresis was observed, yet urine kallikrein and urine kinin excretions remained unmodified.