The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection
Open Access
- 2 January 2009
- journal article
- research article
- Published by Springer Nature in Virology Journal
- Vol. 6 (1) , 109
- https://doi.org/10.1186/1743-422x-6-109
Abstract
The infectious pathway of the non-enveloped Human Papillomavirus Type 16 (HPV16) includes binding to the cell surface, clathrin-mediated endocytosis, and penetration into an endosome. HPV16 infection was shown to decrease in the presence of the lysosomotrophic neutralizing agent ammonium chloride (NH4Cl). NH4Cl neutralizes acidic endo-lysosome compartments, thus suggesting that pH was responsible for PV capsid conformational changes leading endosome escape.This publication has 41 references indexed in Scilit:
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