What Can Progeroid Syndromes Tell Us About Human Aging?
- 3 September 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5689) , 1426-1431
- https://doi.org/10.1126/science.1102587
Abstract
Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.Keywords
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