INFLUENCE OF DOSE AND FIBER TYPE ON RESPIRATORY MALIGNANCY RISK IN ASBESTOS CEMENT MANUFACTURING

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Abstract
Information concerning the risk of respiratory malignancy in relation to duration, degree and fiber type of exposure to asbestos in a manufacturing cohort of 5645 with long-term follow-up was provided. Excess mortality for this cause was found in groups with moderate and high cumulative exposure (standard mortality ratios of 290 and 226). Analysis of the influence of components of total exposure dose (duration, average concentration) revealed no detectable excess risk in persons employed for less than 2 yr or with low-degree average exposure. Exposure to [potential carcinogens] corcidolite (blue) fiber in addition to the predominantly used chrysotile in pipe making appeared to be associated with higher risk than was exposure to chrysotile alone.

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