Activity of antioxidant enzymes of the ischemic myocardium
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Bulletin of Experimental Biology and Medicine
- Vol. 93 (1) , 38-40
- https://doi.org/10.1007/bf00837546
Abstract
Activation of lipid peroxidation during myocardial ischemia may be determined by the reduction of the enzymatic antioxidant cell protection. Evidence from the analysis of variation in the activity of superoxide, dismutase, glutathione peroxidase and catalase in experimental myocardial ischemia in rats, induced by ligation of the left descending artery of the heart supports this idea. In the early period of ischemia (1-3 h), the activity of superoxide dismutase and glutation peroxidase markedly decreases. In the periischemic zone, the fall in the enzymatic activity is not so pronounced. The activity of the enzymes does not reach the basal level 5 days after the operation.This publication has 3 references indexed in Scilit:
- MOLECULAR MECHANISMS OF THE ANTI-OXIDANT EFFECT IN THE TREATMENT OF CARDIOVASCULAR-DISEASES1980
- Superoxide radical and superoxide dismutaseAccounts of Chemical Research, 1972
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951